Bone Marrow Pressure in Leukemic and Non-Leukemic Patients

Targeting the leukemic bone marrow microenvironment

Long-term culture of normal and leukemic human bone marrow.

Clonal culture systems using semisolid media for the detection of granulocyte-macrophage (Bradley and Metcalf 1966; Pike and Robinson 1970; Pluznik and Sachs 1966), erythroid (Stephenson et al. 1971), lymphoid (Fibach et al. 1976; Metcalf et al. 1975a; Sredni et al. 1976) and megakaryocytic (Metcalf et al. 1975b) progenitors have contributed greatly to investigations of hematopoiesis. Unfortuna...

Cellular Activities in Tissue Cultures of Leukemic Human Bone Marrow.

Bone marrow specimens were obtained by aspiration from the sternum. Two to 3 ml. of aspirate were injected into a test tube containing 9 ml. of tissue culture medium and 1 ml. of heparin ( Liquaemin heparin, Organon ) . Bone marrow particles were collected with a capillary pipette from the sediment and from the fatty surface layer. The bone marrow particles were transferred into a second and th...

Chemical studies of normal and leukemic bone marrow.

Modeling The Bone Marrow Microenvironment's Influence on Leukemic Disease.

1 Alexander B. Osborn Hematopoietic Malignancy and Transplantation Program of the Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine, USA 2 Department of Neurobiology and Anatomy, West Virginia University School of Medicine, USA 3 Department of Microbiology, Immunology and Cell Biology, Robert C. Byrd Health Sciences Center, West...